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Background and aims Delayed perforation is a rare complication in therapeutic colonoscopy, and it is severe and sometimes lethal.In this study, we report ona new minimally invasive method for the treatment of delayed colonic perforation.Patients and methods Three patients with delayed colonic perforation accepted our therapy, which involves 3 steps: (1) dosure with endoclips and loop, (2) overtube placement and (3) antibiotic wash through a nasobiliary tube.