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  5. Estrogen attenuates P2X3 receptor-mediated pain signal transduction via ERalpha and GPR30

Estrogen attenuates P2X3 receptor-mediated pain signal transduction via ERalpha and GPR30

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：lc813
【摘 要】
：
Estrogen has been reported to affect pain perception, although the underlying mechanisms remain unclear.In this investigation, pain behavior testing, patch clamp recording and immunohistochemistry wer
【作 者】
：
Bei Ma 
【机 构】
：
Second Military Medical University , China
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
17(β)-estradiol P2X3 receptor pain 
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Estrogen has been reported to affect pain perception, although the underlying mechanisms remain unclear.In this investigation, pain behavior testing, patch clamp recording and immunohistochemistry were used on rats and transgenic mice to determine which estrogen receptors and the related signaling pathway are involved in the rapid modulation of estrogen on P2X3 receptor-mediated events.The results showed that 17(β)-estradiol rapidly inhibited pain induced by a,(β)-methylene ATP (a,(β)-me-ATP), a P2X1 and P2X3 receptor agonist in ovariectomized rats and normal rats in diestrus.
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