Calpain介导低氧诱导的肺动脉高压肺血管重构

来源 :2016第十一届心血管药理专业委员会全国心脑血管药理学术会议 | 被引量 : 0次 | 上传用户：zsjingling

【摘要】

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目的:研究calpain在低氧诱导肺动脉高压肺血管重构中的作用及机制.方法:SD大鼠随机分为低氧组和对照组.通过插管法测定大鼠右心室收缩压及肺动脉平均压,通过右心室/(左心室+室间隔)比值评价右心肥厚指数,通过HE染色检测血管重构情况,实时荧光定量PCR及Westem Blot检测肺动脉CAPN-1、CAPN-2和CAPN mRNA及蛋白表达.原代培养的大鼠肺动脉平滑肌细胞,分为4组:对照组、对照

【作者】

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张卫芳祝田田熊爱珍葛晓月胡长平

【机构】

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南昌大学第二附属医院药学部中南大学药学院药理学系,长沙410078

【出处】

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2016第十一届心血管药理专业委员会全国心脑血管药理学术会议

【发表日期】

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2016年11期

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Calpain介导低氧诱导的肺动脉高压肺血管重构

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