Objectives:There are a many reports about functional dyspepsia (FD) and it’s risk factor, which focused more on the overall disease or it subtypes. Our research focused on FD symptoms spectrum, to evaluate the prevalence of FD symptoms spectrum in the differences regions and different levels of hospitals in china and it’s risk factors. Method:We analyzed data of943cases of FD patients who participate face-to-face questionnaire survey in the Gastroenterology Outpatient Department in25hospitals5cities in china, From June2008to November2009. Baseline demographic data, dyspepsia symptom data, anxiety, depression, sleep disorder and personal data were analysed.Result:1:Of943patients who had FD, postprandial fullness, early satiety, epigastric pain and epigastric burning accounted for66.6%,24.3%,32.2%and17.5%, respectively.2:FD symptoms spectrum and mental factors and sleep disorder were different between different cities and different levels of hospitals; postprandial fullness, epigastric pain and epigastric burning had higher percentage in Beijing and Xian (North of China) in comparison to Shanghai and Guangzhou (south of China)(P<0.001), early satiety had higher percentage in Wuhan than Guangzhou (P<0.05). The highest percentage of anxiety, depression and sleep disorder were in Beijing, significant higher than other cities in south of china (P<0.05). Postprandial fullness and epigastric pain distributed with patients from tertiary hospital, significantly more than those in secondary and primary hospital (P<0.05), also FD patients from tertiary hospitals were subjected to more depression and anxiety than patients from secondary and primary hospitals (P<0.005).3:Multivariate analysis of the risk factors showed that risk factor of postprandial fullness was middle education level [OR,1.943;95%CI,1.189-3.177; P=0.008], risk factors of early satiety were BMI<18kg/m2, sleep disorder, depression and anxiety [(OR,1.920;95%CI,1.034-3.566; P=0.039),(OR,1.446;95%CI,0.875-1.550; P=0.023),(OR,1.854;95%CI,1.035-3.321; P=0.038) and (OR,1.906;95%CI,0.733-2.132; P=0.013), respectively]; risk factors of epigastric pain were relative with easy manual labor, married status and history of abuse [(OR,1.501;95%CI,1.175-1.918; P=0.001),(OR,1.804;95%CI,1.095-2.971; P=0.02) and (OR,3.988;95%CI,1.503-10.578; P=0.005), respectively], easy manual labor was the only risk factor of epigastric burning [OR,1.735;95%CI,1.308-2.302; P=0.001].4:In the distribution of symptoms of risk factors, postprandial fullness was more susceptible in middle and high education (P=0.004), early satiety was more susceptible in female (P=0.021), epigastric pain and burning were more susceptible in patients who have easy manual labor (P=0.001, P<0.001, respectively).5:In the comparison between male and female we found sleep disorders, depression, and anxiety was significant more in female than male,(P<0.001, P=0.002, P=0.041, respectively), also age, smoker, alcohol drinker, education level and BMI percentage were significant difference between male and female (P<0.05).Conclusions:postprandial fullness was a more frequent symptom of FD patients in China. Almost all symptoms of FD and mental risk factor were higher in north of china and tertiary hospital. Middle educational level is risk factor for postprandial fullness. low BMI, anxiety, depression and sleep disorder are risk factors for early satiety. Easy manual labor is are risk factors of epigastric pain and epigastric burning. Married status and history of abuse are risk factor for epigastric pain only. Early satiety, mental factors (anxiety and depression) and sleep disorder are more likely in female. Age, smoking, alcohol abuse, education level and BMI percentage were significant difference between male and female.