论文部分内容阅读
destruction in vitro [J]. Ann Rheum Dis ,2002,61(10):870-876.[28]KIRKHAMB W,LASSERE M N,EDMONDS J P, et al.Synovial memnrance cytokine expression is predictive of joint damage progression in rheumatiod arthritis :A two-year prospective study(the DAMA GE study cohort)[J].Arth- ritis Rheum,2006,54 (4) :1122-1131.[29]Murphy CA,Langrish CL,Chen Yi. et al.Divergent Pro- and antiinflammato- ry roles for IL-23 and IL-12 in jont autoinlnlune inflammation[J].The Journ- al of Experimental Medicine,2003,198(12):1951-1957.[39] Cua DJ,Shedock J,Chen Y, et al.Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain [J].Nature,2 003,421(6924):744-748.[31]John L Langowski, Xueqing Zhang, Lingling Wu,et a1.IL23 promoted tum- our incidence and growth[J].Nature,2006,442:461-465.[32]Kaiga T, Sato M, Kaneda H, et al. Systemic administration of IL-23 induce potent antitumor immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12[J].Immunol,2007,178:75 71-7580.[33]Kyle I Happel,Mingquan Zheng,Erana Young,et a1.Cutring edge:roles of Toll-like receptor 4 and IL-23 in IL-17expression in response to klebsiella pneumoniae infection[J].J Immunology,2003,170(9):4432-4436.[34]Giorgio Fedele, Paola Stefanelli, Fabiana Speusieri, et a1.Bordetella pertuss- is-infeected human monecyte-derived dendritic cellscundergo maturation an- d induce Th1 polarization and interleukin-23 expression [J].Infection and I- mmunity,2005,73(3):1590-1597.5、RA患者(活动组+缓解组)不同X线分期IL-23的水平分别为:Ⅰ期(191.09±32.45)pg/ml,Ⅱ期(219.64±41.80)pg/ml,Ⅲ期(296.98±41.66)pg/ml,Ⅳ期(322.36±46.16)pg/ml,Ⅰ期与Ⅱ期、Ⅲ期、Ⅳ期比较差异均有统计学意义(P均<0.05),Ⅱ期与Ⅲ期、Ⅳ期比较差异有统计学意义(P均<0.05),Ⅲ期与Ⅳ期比较差距无统计学意义(P>0.05)。结论1、IL-23在活动期RA患者血清中水平明显增高。2、IL-23与DSA28评分呈正相关,其水平可作为RA活动参考指标,IL-23可能参与了RA的发病。3、IL-23与IL-17呈正相关,说明IL-23与IL-17关系密切。4、IL-23水平随X线分期不同而有差异,IL-23可能参与RA骨侵蚀,有望成为治疗靶点。