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目的:探讨硫酸镁溶液经微量气泵吸入治疗小儿毛细支气管炎的临床疗效及安全性,寻求硫酸镁控制毛细支气管炎急性喘憋发作的最佳给药途径。方法:选择在我科住院的毛细支气管炎患儿90例,随机分为三组,在抗感染、对症等综合治疗的基础上:硫酸镁吸入组给予25%MGSO4溶液0. 1-0. 2ml/(kg.次)吸入,2～6次/d,连用3～5d;硫酸镁静点组给予25%MGSO4溶液0. 1～0. 2ml/(kg.次),稀释为0. 25%-0. 50%浓度后缓慢匀速静点,1～2次/d,连用3～5d;对照组仅给予等量的生理盐水吸入,所用装置及治疗方法同硫酸镁吸入组。观察各组用药前后血气改变、临床评分下降程度及每日临庆症状、体征的变化。结果:(1) 治疗24h后,硫酸镁吸入组动脉血氧分压(PaO2) 、动脉血氧饱和度(SaO2) 、动脉血二氧化碳分压(PaCO2) 与治疗前相比均有明显改善(P<0. 01) ,静点组治疗前后各项血气指标虽有一定程度改善,但无统计学意义(P>0. 05) ,对照组治疗前后上述指标均无改善(P>0. 05) ;治疗后组间两两比较结果显示硫酸镁吸入组上述指标改善情况明显优于硫酸镁静点组和对照组(P<0. 01) 。(2) 硫酸镁吸入组与静点组在临床评分下降程度、临床症状体征持续时间及住院天数方面优于与对照组(P<0. 01) ,硫酸镁吸入组与静点组相比上述指标也有明显改善(P<0. 01) 。(3) 治疗后硫酸镁吸入组临床有效率达93. 33%,优于静点组有效率(73. 33%)(x2=3. 92,P<0. 05) 及对照组有效率(16. 67%)(x2=14. 8,P<0. 001) ;硫酸镁静点组与对照组相比总有效率也有增高(x2=9. 27,P<0. 05) 。结论:硫酸镁气雾吸入或静脉点滴治疗毛细支气管炎,均可有效新疆医科大学医学硕士学位论文缓解喘憋,改善缺氧,促进肺部哆音的吸收和肺功能的恢复,缩短病程:硫酸镁气雾吸入给药较静脉全身性给药显效快、疗效好、副作用少,故是临床上辅助治疗毛细支气管炎的一种安全、有效、经济、简便的给药途径。关键词:硫酸镁:毛细支气管炎;气雾吸入;疗效Analyzing the effeet on inhaling Magnesium Sulfate to treat Infants with BronehiolitiSGrauduate:LIU LuProduetor:Zhang Wei一Ping Abstr8Ct objeetive:To evaluate the theraPeutie effeets and safety on inhalation ofMagnesium Sulfate in the treatment of aeute bronehiolitis in infants:to searehfor the best theraPy method when aeute wheeze attaek.Methods:Total ninetyin介mts with bronehiolitis hosPitalized in dePartment of Pediatries wererandomly divided into 3 grouPs and resPeetively assigned to reeeive either 25%magnesium sulfate infusion(0.1一0.2ml瓜创time)inhalation through a PumPnebulizer or 25%magnesium sulfate intravenous injection(0.1、0.2ml/k幼ime)or normal saline inhal以ion on the base of same eomPrehensive treatment.Toobserve ehange of blood gas、Dobson seore、elinieal symPtoms and signs ofthree grouPs.Results:(l)24 hours later, PaO2.Sa02 and PaCOZ level inmagnesium sulfate inhalation grouP were better than that of Pre一treatment(P<0 .01);That of intravenous injeetion grouP and eontrol grouP were notsignifieantly ehanged(P>0.05).(2)Magnesium sulfate inhalation grouP andintravenous injeetion grouP were suPerior to eontrol grouP in terms of theimProvement of elinieal Dobson seores,elinieal sylnPtoms,signs eontinuoustime and hosPital days(P<0.01);Magnesium sulfate inhalation grouP were alsosuPerior to intravenous injeetion grouP.(3)After treatment,Clinieal total effieaey一2一