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用离体大鼠皮肤为渗透屏障，研究了盐酸普萘洛尔在杜促灵、油酸、Ａｚｏｎｅ作用下的透皮效果．在盐酸普萘洛尔的饱和水溶液中促进效果大小依次为５０ｇ／ＬＡｚｏｎｅ，１００ｇ／Ｌ杜促灵、２００ｇ／Ｌ．杜促灵、５０ｇ／Ｌ杜促灵、５０ｇ／Ｌ油酸，并且杜促灵的滞后时间比Ａｚｏｎｅ短．在聚乙烯醇为成膜材料，１００ｇ／Ｌ杜促灵为促进剂制成的膜剂用于家兔皮肤进行药物动力学研究．结果表明，盐酸普萘洛尔膜剂透皮给药后以零级方式吸收进入血液循环．
The rat skin permeation barrier was used to study the transdermal effect of propranolol hydrochloride under the action of Du Ling, oleic acid and Azone. The promotion effect of propranolol hydrochloride in saturated aqueous solution was 50g / LAzone, 100g / L Du Ling, 200g / L. Du Ling Spirit, 50g / L Du Ling, 50g / L oleic acid, and Du Ling spiritual lag time shorter than Azone. In polyvinyl alcohol as a film-forming material, 100g / L Du Ling for the accelerator made of film for rabbit skin pharmacokinetic study. The results showed that, after transdermal administration of propranolol hydrochloride membrane, the blood was absorbed into the bloodstream in a zero-order manner.