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目的调查了解盐城市接受美沙酮维持治疗(MMT)的吸毒人员艾滋病毒(HIV)、梅毒、乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)感染状况,为制定相应疾病干预措施提供科学依据。方法对262例美沙酮门诊入组的吸毒人员分别进行抗HIV、梅毒螺旋体(TP)抗体、HBsAg和抗HCV检测,TP抗体阳性者做P抗体试验(TPPA)确诊、做梅毒快速血浆反应素试验(RPR)并对结果进行分析。结果 262例吸毒人员中未检出HIV抗体阳性者,梅毒、HBV和HCV感染率分别为19.47%(51例)、11.45%(30例)和58.02%(152例);梅毒感染者中RPR阳性15例(29.41%),滴度分别为1∶1～1∶32;梅毒和HBV合并感染者2例(0.76%),梅毒和HCV合并感染者39例(14.89%),HBV和HCV合并感染者17例(6.49%)。结论盐城地区美沙酮门诊服药人员梅毒、HBV、HCV的感染率均较高,需加大综合防治力度。
Objective To investigate the status of HIV, syphilis, hepatitis B and hepatitis C virus (HCV) infection among drug addicts receiving methadone maintenance treatment (MMT) in Yancheng and provide a scientific basis for formulating the corresponding disease interventions . Methods A total of 262 methadone clinics were enrolled in this study. Anti-HIV, TP, HBsAg and anti-HCV were detected respectively. TP antibody positive patients were diagnosed by TP antibody, and syphilis rapid plasma reactive element test RPR) and analyze the results. Results Among the 262 drug addicts who were HIV positive, the prevalences of syphilis, HBV and HCV were 19.47% (51 cases), 11.45% (30 cases) and 58.02% (152 cases), respectively. The positive rates of RPR in syphilis 15 cases (29.41%) with titers of 1: 1-132, 2 cases of syphilis and HBV infection (0.76%), 39 cases of syphilis and HCV infection (14.89%), HBV and HCV infection 17 cases (6.49%). Conclusion The prevalence of syphilis, HBV and HCV in methadone outpatient service workers in Yancheng area are high, so it is necessary to intensify the comprehensive prevention and treatment.