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目的分析四川省遂宁市2005-2012年急性弛缓性麻痹(AFP)病例流行病学特征和评价监测系统运转情况。方法采用描述流行病学分析AFP病例流行病学特征,按全国AFP监测方案要求评价监测系统运转情况。结果 2005-2012年全市共报告AFP病例146例,均为非脊髓灰质炎病例,死亡4例,1例Ⅲ型疫苗衍生脊髓灰质炎病毒VDPV(vaccine-derived polioviruses)病例。15岁以下儿童AFP病例平均报告发病率3.25/10万;病例分布在全市2区3县,大英县2008、2011年和安居区2009、2011年无AFP病例报告。发病以5岁以下儿童为主(69.86%);男女性别比为2.11∶1;免疫史3次及以上者占79.45%;临床诊断以格林巴利综合征为主(22.60%)。2005-2012年,平均48 h内调查率100%、合格粪便标本采集率91.10%、粪便标本7 d内送达率98.63%、随访表75 d内送达率96.58%。结论 2005-2012年遂宁市AFP监测系统的敏感性和及时性达到WHO和卫生部要求,及时发现了VDPV病例。
Objective To analyze the epidemiological characteristics of acute flaccid paralysis (AFP) cases in Suining City, Sichuan Province from 2005 to 2012 and evaluate the operation of monitoring system. Methods Descriptive epidemiological analysis of the epidemiological characteristics of AFP cases, according to the national AFP monitoring program to evaluate the monitoring system operation. Results A total of 146 AFP cases were reported in the city from 2005 to 2012, all of which were non-poliomyelitis cases, with 4 deaths and 1 case of type III vaccine-derived polioviruses (VDPV). The average incidence of AFP cases in children under 15 years of age was 3.25 / 100,000. The cases were distributed in 3 districts in 2 districts of the city. There were no AFP cases in 2009 and 2011 in Daying County, Dalian. The incidence of children under 5 years of age (69.86%); sex ratio of 2.11:1; immunization history of 3 times and above accounted for 79.45%; clinical diagnosis of Guillain-Barre syndrome (22.60%). In 2005-2012, the average investigation rate was 100% within 48 h, 91.10% of qualified stool specimens, and 98.63% of stool specimens within 7 days. The rate of delivery within 96 days was 96.58%. Conclusion The sensitivity and timeliness of AFP monitoring system in Suining from 2005 to 2012 reached the requirements of WHO and Ministry of Health, and timely discovered the cases of VDPV.