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本文通过834例原发性肝癌(PHC)资料分析,筛选出度生PHC的4个主要危险因素:HBV、家族肿瘤史、性别及肝炎史;其中HBV是导致PHC发生的重要外因,内因为家族肿瘤史(遗传因素),而肝炎史是无HBV感染者发生PHC的危险因素。伴HBV感染的PHC临床特点为:硬化型显著多(P<0.05);远期疗效较差,1年以上生存率显著低(P<0.05)。提示有HBV感染、家族肿瘤史及肝炎史的男性应作为PHC二级预防的主要对象,加强随访、复查,以达到肝癌的早期诊治,提高生存率。
This article analyzes 834 cases of primary liver cancer (PHC) data and screens out four major risk factors for PHC: the history of HBV, family history of cancer, gender, and history of hepatitis; HBV is an important external cause of PHC. History of oncology (genetic factors), while history of hepatitis is a risk factor for PHC in those without HBV infection. The clinical features of PHC with HBV infection were: sclerosing type was significantly more (P<0.05); long-term curative effect was poor, and the survival rate was more than one year was significantly lower (P<0.05). It is suggested that men with HBV infection, family history of oncology, and history of hepatitis should be the main targets for secondary prevention of PHC. Follow-up and review should be strengthened to achieve early diagnosis and treatment of liver cancer and improve survival.