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本工作比较自发性高血压大鼠(SHR)和肾性高血压大鼠(RHR)及对照大鼠红细胞膜Ca~(2+),Mg~(2+)-ATP酶(钙泵)活性及其对CaM、TFP、川芎嗪和硝苯吡啶(Nifedipine、Nif)等的反应,目的是分析高血压时钙泵功能障碍的机理,并寻找能有效提高钙泵活性的药物,为高血压防治提供有效措施。 结果表明SHR及RHR基础钙泵活性明显低于相应对照大鼠钙泵活性;原因之一可能与高血压动物质膜钙泵对钙泵抑制剂TFP的敏感性增加有关,对RHR,川芎嗪作用很类似TFP。提示此药有CaM拮抗作用。Nif除了公认为钙通道阻断剂外,本实验表明对RHR它还有激活钙泵的作用。
This study compared the activities of Ca ~ (2 +), Mg ~ (2 +) - ATPase (Ca2 +) in erythrocyte membrane in spontaneously hypertensive rats (SHR) and renal hypertensive rats (RHR) Its response to CaM, TFP, ligustrazine and Nifedipine (Nif) is intended to analyze the mechanism of calcium pump dysfunction in hypertension and to find drugs that can effectively increase the activity of calcium pump for the prevention and treatment of hypertension Effective measures The results showed that the basal calcium pump activity of SHR and RHR was significantly lower than that of corresponding control rats. One of the reasons may be related to the increase of the sensitivity of plasma pump membrane calcium pump to TFP in hypertensive animals and to the effects of tetramethylpyrazine Very similar to TFP. Tip this drug has CaM antagonism. In addition to the Nif recognized as a calcium channel blocker, this experiment showed that it has the role of activation of calcium pump on RHR.