药物的透皮吸收主要经过经表皮途径。研究表明药物在正常皮肤比无附属器的皮肤吸收得快而多,可见皮肤附属器对透皮吸收有一定的作用。本文作者应用体内实验方法研究皮肤附属器对两种亲脂性不同的类固醇化合物透皮吸收的重要性。根据 Illel 等描述的方法人工损伤无毛鼠的皮肤,使其成为无附属器的瘢痕皮肤。药 Transdermal absorption of the drug is primarily via the epidermal route. Studies have shown that the absorption of the drug in the normal skin is faster and more than the skin without an accessory, showing that the skin appendage has a certain effect on the transdermal absorption. The authors used in vivo experimental methods to study the importance of skin adnextiles for percutaneous absorption of two different lipophilic steroid compounds. Human hairless skin was artificially damaged according to the method described by Illel et al., Making it an anaplastic scarskin. medicine