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应用ＰＣＲ－端粒重复序列扩增法（ＴＲＡＰ）检测３１例肺癌、４例癌旁及２６例肺良性肿瘤患者肿瘤组织的端粒酶活性表达。结果显示，肺癌组织中端粒酶活性表达率为８０．６％（２５／３１）、癌旁组织无表达、肺良性肿瘤组织表达率为７．７％（２／２６）。端粒酶活性表达与肺癌分化程度呈负相关，与肺癌分期无关。有及无淋巴结转移者的端粒酶活性表达率有显著性差异。提示端粒酶在肺癌的发生、发展及转移过程中皆起重要作用；其在肺癌组织中的高表达有望成为肺癌诊断、鉴别诊断的一项强有力的生物学指标。
PCR-telomere repeat amplification (TRAP) was used to detect the expression of telomerase activity in 31 cases of lung cancer, 4 cases of paratumor and 26 cases of lung benign tumors. The results showed that the expression rate of telomerase activity in lung cancer tissues was 80.6% (25/31), no expression was observed in adjacent tissues, and benign lung tumor tissues were expressed in 7.7% (2/26). The expression of telomerase activity was negatively correlated with the degree of lung cancer differentiation and had no relationship with the stage of lung cancer. There was a significant difference in the expression rate of telomerase activity in patients with and without lymph node metastasis. It is suggested that telomerase plays an important role in the occurrence, development and metastasis of lung cancer; its high expression in lung cancer tissue is expected to be a powerful biological indicator for the diagnosis and differential diagnosis of lung cancer.