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目的探讨Galectin-3在肾细胞癌中的表达及意义。方法采用免疫组化二步法检测Galectin-3在肾细胞癌中的表达,并对肾细胞癌组织进行系统的病理学检查和分析。结果Galectin-3表达与肾细胞癌的分级和分期均成负相关(P<0.05)。Galectin-3低表达者(1~2级)术后5年生存率明显低于高表达者(3~4级)(P<0.05)。结论Galectin-3与临床分期结合能更好地判断肾细胞癌的预后,Galectin-3低表达者易发生转移且预后差。
Objective To investigate the expression of Galectin-3 in renal cell carcinoma and its significance. Methods The expression of Galectin-3 in renal cell carcinoma was detected by immunohistochemical two-step method. The pathological examination and analysis of renal cell carcinoma were performed. Results The expression of Galectin-3 was negatively correlated with the grade and stage of renal cell carcinoma (P <0.05). The 5-year survival rates of patients with low expression of Galectin-3 (grade 1 ~ 2) were significantly lower than those with high expression (grade 3 ~ 4) (P <0.05). Conclusions The combination of Galectin-3 and clinical staging can better judge the prognosis of renal cell carcinoma. The low expression of Galectin-3 is prone to metastasis and the prognosis is poor.