论文部分内容阅读
目的通过观测充血性心力衰竭不同病变时期病人外周血心肌肌钙蛋白I(cTnI)、BNP浓度变化,以比较和探讨两者在冠心病与非冠心病所致的充血性心力衰竭中的浓度变化和意义。方法选取心衰病人(病例组)60例,健康志愿者(对照组)20名,分别对病例组、对照组留取血清标本。采用夹心法原理、微粒子酶免疫分析技术检测上述两组血清中BNP、cTnI水平,并对测定结果进行统计学处理。结果心力衰竭组血浆BNP浓度为(1426.3±512.1)ng/L,cTnI浓度为(769.6±266.3)ng/L,与正常对照组BNP(46.9±33.3)ng/L,cTnI(27.9±12.1)ng/L比较差异有统计学意义(P<0.01)。BNP浓度心功能I度CHF(529.5±236.9)ng/L、度CHF(1129.6±466.5)ng/L、度CHF(2736.5±996.2)ng/L,两两比较有统计学意义(P<0.05);cTnI浓度I度CHF为(366.6±169.6)ng/L、度CHF(1535.1±522.6)ng/L、度CHF(1719.4±679.4)ng/L,I度与度、度比较差异有统计学意义(P<0.05),而度和度比较差异无统计学意义(P>0.05)。结论(1)CHF病人血清BNP,cTnI浓度均明显升高(P<0.05),升高程度依次为III度CHF病人、II度CHF病人、I度CHF病人。表明血清BNP、cTnI的浓度与CHF的严重程度有关,CHF越严重,血清BNP、cTnI浓度越高。可以作为心力衰竭分级的一个良好的诊断指标。
Objective To observe the change of cardiac troponin I (cTnI) and BNP concentration in patients with congestive heart failure at different stages of disease to compare and explore the concentration changes of both in coronary heart disease and non-coronary heart disease congestive heart failure And meaning. Methods Sixty patients with heart failure (case group) and 20 healthy volunteers (control group) were enrolled in the study. Serum samples were collected from the case group and the control group respectively. Sandwich method was used to detect the levels of BNP and cTnI in serum of the above two groups by means of microparticle enzyme immunoassay, and the results were statistically analyzed. Results The plasma BNP concentration was (1426.3 ± 512.1) ng / L and the cTnI concentration was (769.6 ± 266.3) ng / L in the heart failure group, which was significantly lower than those in the normal control group (46.9 ± 33.3 ng / / L, the difference was statistically significant (P <0.01). The BNP level in CHF patients was 529.5 ± 236.9 ng / L, the mean CHF was 1129.6 ± 466.5 ng / L, the CHF was 2736.5 ± 996.2 ng / L, with significant difference (P <0.05) ; CHF of CHF (1535.1 ± 522.6) ng / L, CHF of CHF (1719.4 ± 679.4) ng / L, I degree and degree of CHF were 366.6 ± 169.6 ng / L for cTnI, (P <0.05), but there was no significant difference between degrees and degrees (P> 0.05). Conclusions (1) Serum levels of BNP and cTnI were significantly increased in CHF patients (P <0.05). The progression of CHF patients were III degree CHF patients, II degree CHF patients and I degree CHF patients. Serum BNP, cTnI concentration and severity of CHF, CHF more serious, serum BNP, cTnI concentration higher. Can be used as a good diagnosis of heart failure grading.