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已知紫草属(Lithospermum)和地笋属(Lycopus)植物提取物中的酚性成分能被高活化的儿茶酚氧化酶所催化氧化。其氧化产物具有抗促性腺活性。此氧化过程也可由高锰酸钾或溶解空气中氧(自动氧化)来完成。作为这些植物的主要酚性成分咖啡酸经氧化后仅有弱的抗促性腺活性,但其天然存在的衍生物如迷迭香酸(rosmarinicacid)及其合成的酯经氧化后均为有效的促性腺抑制剂。本文研究了咖啡酸及其衍生物的氧化反应、氧化产物的生成和它们的抗促
It is known that phenolic components in plant extracts of Lithospermum and Lycopus can be catalytically oxidized by highly activated catechol oxidase. Its oxidation products have anti-gonadal activity. This oxidation can also be done by potassium permanganate or dissolved oxygen in the air (autoxidation). As the main phenolic component of these plants, caffeic acid, after oxidation, has only weak anti-gonadal activity but its naturally occurring derivatives, such as rosmarinic acid and its synthetic esters, are effectively oxidized Gonad inhibitor. This article studies the oxidation of caffeic acid and its derivatives, the formation of oxidation products and their resistance