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本文报道1994年在福建长乐进行的大规模胃癌防治计划,通过胃镜、血液检查及问卷检查,发现30例胃癌及214例消化性溃疡,幽门螺杆菌的感染率在各类人群中为67％至94％不等。在年龄36岁至65岁组中,长乐地区幽门螺杆菌的感染率明显高于香港,无论是幽门螺杆菌的感染者或非感染者,胃窦肠上皮化生发现率在长乐都高于香港,在长乐,胃窦肠上皮化生发现率高于胃体肠上皮化生。长乐及香港的Cag-A阳性菌株与各种胃疾病有明显关系,在无症状组中,Cag-A阳性菌株在长乐占72％,明显高于香港的29％。Cag-A阳性菌株与胃炎、粘膜萎缩、肠上皮化生、不典型增生和胃癌有明显关系。问卷发现多喝茶及多进食蔬菜有保护作用,而抽烟及饮酒人群或进食咸鱼有较多机会形成胃癌。
This article reported on a large-scale prevention and control program for gastric cancer in Changle, Fujian Province in 1994. Through gastroscopy, blood tests, and questionnaires, 30 cases of gastric cancer and 214 peptic ulcers were found. The infection rate of Helicobacter pylori was 67% in various populations. 94% range. In the age group of 36 to 65 years, the infection rate of Helicobacter pylori was significantly higher in Changle than in Hong Kong. Regardless of the infection or non-infection of Helicobacter pylori, the discovery rate of gastric antral intestinal metaplasia was higher in Changle than in Hong Kong. In Changle, the discovery rate of gastric antral intestinal metaplasia was higher than that of gastric corpus intestinal metaplasia. The Cag-A positive strains in Changle and Hong Kong have a significant relationship with various gastric diseases. In the asymptomatic group, Cag-A positive strains accounted for 72% in Changle, which was significantly higher than 29% in Hong Kong. Cag-A positive strains were significantly associated with gastritis, mucosal atrophy, intestinal metaplasia, atypical hyperplasia, and gastric cancer. The questionnaire found that drinking more tea and eating more vegetables have a protective effect, while smoking and drinking groups or eating salted fish have more chances to develop gastric cancer.