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目的检测少精子症、无精子症患者体内血清性激素水平并结合睾丸体积的变化,探讨其临床意义。方法将197例少精子症、无精子症患者分为3组:A组38例(无精子症患者),B组113例(少精子症患者),C组46例(重度少精子症患者),D组(选用35例正常精液的健康男性为对照组)。均进行性激素和睾丸容积测定。结果 B组FSH、LH虽均较正常精液组高,但无显著性意义(P>0.05)。A、B、C组FSH LH、睾丸体积均有差异(P<0.05),T均呈显著性降低(P<0.01)。A组及C组FSH、LH均显著高于D组(P<0.01),且A组FSH升高幅度显著大于C组,PRL、T均呈显著性升高(P<0.01)。结论 FSH结合睾丸容积可作为判断睾丸生精功能的重要指标,血清性激素水平检测对于无精子症、少精子症(特别是重度少精子症)患者的病因分析、制订治疗方案和预后评估具有重要的临床意义。
Objective To detect the levels of serum sex hormones in patients with oligospermia and azoospermia combined with the changes of testicular volume to explore its clinical significance. Methods A total of 197 oligozoospermia and azoospermia patients were divided into 3 groups: group A (38 cases), group B (113 cases), group C (46 cases) (group with severe oligospermia) , D group (35 normal semen healthy men as the control group). Sex hormones and testicular volume were measured. Results Although FSH and LH in group B were higher than those in normal semen group, there was no significant difference (P> 0.05). FSH LH, testicular volume in groups A, B and C were all significantly different (P <0.05), while T was significantly lower (P <0.01). The FSH and LH in group A and group C were significantly higher than those in group D (P <0.01). The increase of FSH in group A was significantly greater than that in group C, and the levels of PRL and T were significantly increased (P <0.01). Conclusion FSH combined with testicular volume can be used as an important indicator of testicular spermatogenesis. The detection of serum sex hormone levels is important for the analysis of the causes of azoospermia, oligospermia (especially severe oligospermia), development of treatment plans and prognosis Clinical significance.