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种族不同发生的药物不良反应有所不同。例如,日本人和爱斯基摩人中有不少人是快乙酰化者,使用异烟肼时易产生肝损害;而英国人和犹太人中慢乙酸化者达 60—70％,这些人使用异烟肼易产生周围神经炎。在葡萄糖- 6- 磷酸脱氢酶(G—6—PD)缺乏者中,非洲黑人主要是缺乏G—6—PD—A,在服用伯氨喹、磺胺等药物出现溶血性贫血时,红细胞的损害不太严重,而高加索人主要缺乏G—6-PD—B,使用上述药物时,红细胞的损害就比较严重。对于心得安减慢心率的作用,中国人比美国人敏感,同样的治疗剂量,美国人表现为治疗作用,而中国人就可能出现不良反应。
Adverse drug reactions that occur in different races vary. For example, many people in Japan and Eskimos are quick acetylators, who develop liver damage when using isoniazid; 60-70% of those slow-engulfing in Britons and Jews who use isoniazid Easy to produce peripheral neuritis. In the absence of glucose-6-phosphate dehydrogenase (G-6-PD), African blacks mainly lack G-6-PD-A. When taking primaquine and sulfanilamide, hemolytic anemia Less severe damage, while Caucasians mainly lack G-6-PD-B, the use of these drugs, the damage of red blood cells is more serious. Americans are more sensitive to the effects of heart rate relief than Americans. The same dose of treatment shows that Americans show a therapeutic effect, while Chinese people may experience adverse reactions.