目的　了解假单胞菌医院感染状况及对抗菌药物的敏感率。方法　调查 1994年 7月～ 1998年 6月 4年间发生的假单胞菌医院感染 332例 ,分析原发病、诱发因素、临床特点、血白细胞、病原菌分布及K- B法药敏情况。结果　血液系统疾病、慢性阻塞性肺气肿和外伤患者易引起假单胞菌医院感染 ,常见感染部位为呼吸道、泌尿道。结论　机体免疫功能受损者易患假单胞菌医院感染 ,病原菌对环丙沙星、阿米卡星、头胞他啶、多粘菌素 B的敏感性较好。 Objective To understand the prevalence of Pseudomonas nosocomial infection and its sensitivity to antimicrobial agents. Methods A total of 332 cases of Pseudomonas nosocomial infection occurred during the four years from July 1994 to June 1998 were investigated. The primary disease, predisposing factors, clinical features, distribution of white blood cells, pathogenic bacteria and drug sensitivity of K-B method were analyzed. Results Hematologic diseases, chronic obstructive pulmonary emphysema and trauma patients easily lead to Pseudomonas nosocomial infection. The common infection sites were respiratory tract and urinary tract. Conclusion The immunocompromised patients are susceptible to Pseudomonas nosocomial infection. The pathogenic bacteria are sensitive to ciprofloxacin, amikacin, ceftazidime and polymyxin B.