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研究对象为1岁时接种过3剂DTP和2剂口服脊髓灰质炎疫苗(OPV)且对麻疹-流行性腮腺炎-风疹(MMR)疫苗、DTP和OPV无禁忌证的14～23月龄婴儿。将这些婴儿随机分为两组。试验组(405人)于第0天接种MMR疫苗、DTP和OPV,第60天接种DTP安慰剂(消毒盐水)和OPV安慰剂(消毒细胞培养液)。对照组(410人)于第0天接种MMR疫苗、DTP安慰剂和OPV安慰剂,第60天接种DTP和OPV。MMR疫苗于右臂作皮下注射,DTP和DTP安慰剂于左臂作肌肉注射。于接种前、接种后第0天、60天和120天采血检测抗9种抗原的抗体滴度。并对试验
Participants were 14 to 23-month-old infants who received 3 doses of DTP and 2 doses of oral polio vaccine (OPV) at 1 year of age and had no contraindications to measles-mumps-rubella (MMR) vaccine, DTP and OPV . The infants were randomly divided into two groups. The test group (405) received MMR vaccine, DTP and OPV on day 0, DTP placebo (sterile saline) and OPV placebo (sterile cell culture) on day 60. The control group (410) received MMR vaccine, DTP placebo and OPV placebo on day 0 and DTP and OPV on day 60. The MMR vaccine was injected subcutaneously in the right arm and DTP and DTP placebo in the left arm for intramuscular injection. Antibody titers of 9 antigens were tested before blooding, 0 days, 60 days and 120 days after inoculation. And test