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目的 检测系统性红斑狼疮 (SLE)患者外周血清基质金属蛋白酶 3 (MMP 3)水平并探讨其临床意义。方法 MMP 3检测采用ELISA方法。结果 SLE患者血清MMP 3水平为99 86ng/ml(中位数 ,下同 )显著高于正常对照组 2 7 82ng/ml (P <0 0 0 1)。SLE患者中 ,发生神经精神性狼疮者MMP 3水平显著高于非神经精神性狼疮患者 (P <0 0 1) ,发生狼疮肾炎者MMP 3亦明显高于无肾损害者 (P <0 0 5 ) ,而发生多发性关节炎和颊部皮疹 /光敏感患者分别与无多发性关节炎和颊部皮疹 /光敏感患者的MMP 3水平差异无显著性 (P >0 0 5 ) ;出现抗dsDNA抗体阳性、低补体C3血症、低白蛋白血症、高IgG血症及血肌酐升高者血清MMP 3水平均分别显著高于无上述表现者 (P <0 0 5 ) ,SLE患者血清MMP 3水平与SLEDAI呈正相关关系 (P <0 0 5 )。结论 SLE患者血清中MMP 3水平显著升高 ,可作为狼疮活动的参考指标之一。MMP 3参与SLE的病理生理过程 ,与SLE的某些临床检验异常表现及狼疮脑、肾等脏器损害有关
Objective To detect the serum level of matrix metalloproteinase 3 (MMP 3) in patients with systemic lupus erythematosus (SLE) and to investigate its clinical significance. Methods MMP 3 detection using ELISA method. Results The level of serum MMP 3 in patients with SLE was 99 86 ng / ml (median, the same below) was significantly higher than the control group 2 7 82 ng / ml (P 0 001). In patients with SLE, the MMP-3 level in patients with neuropathic lupus was significantly higher than those without neuropsychological lupus (P <0.01), and those with lupus nephritis were also significantly higher than those without renal damage (P <0.05 ). There was no significant difference in MMP-3 between patients with polyarthritis and cheek rash / light-sensitive patients and without polyarthritis and cheek rash / light-sensitive patients (P> 0.05). Anti-dsDNA Antibody positive, low complement C3 hyperlipidemia, hypoalbuminemia, hyperglycemia and serum creatinine increased serum MMP 3 levels were significantly higher than those without above-mentioned performance (P <0 05), SLE serum MMP 3 level was positively correlated with SLEDAI (P <0.05). Conclusion The level of MMP-3 in serum of patients with SLE is significantly increased, which may be used as one of the reference indexes of lupus activity. MMP 3 is involved in the pathophysiological process of SLE, which is related to the abnormal performance of some clinical tests of SLE and the damage of lupus brain, kidney and other organs