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目的探讨2型老年糖尿病患者心率变异性(Heart rate variability,HRV)与血清P-选择素变化的相关性。方法选择68例老年糖尿病患者行24h动态心电图检查,测定HRV,包括所有窦性心搏R-R(NN)间期的标准差(SDNN)、全程记录中每5minNN间期平均值的标准差(SDANN)、相邻NN间期差值的均方根(rMSSD),ELISA法检测其血清P-选择素水平,并与40例老年健康对照组比较。结果糖尿病组HRV参数显著低于对照组(P<0.05),而血清P-选择素水平较对照组显著升高(P<0.05),且HRV与血清P-选择素水平具有显著的负相关性(r=-0.27r,=-0.17r,=-0.26,P<0.05)。结论糖尿病患者心脏自主神经功能的改变和血清P-选择素水平的变化具有相关性。
Objective To investigate the correlation between heart rate variability (HRV) and serum P-selectin in type 2 senile patients with diabetes mellitus. Methods Sixty-eight elderly diabetic patients underwent 24-hour ambulatory electrocardiogram (ECG) examination. The HRV was measured, including the standard deviation (SDNN) of all sinus beats RR (NN) interval, the SDANN of every 5- The mean square root mean square difference (rMSSD) between adjacent NNs and the serum P-selectin level were measured by ELISA, and compared with 40 elderly healthy controls. Results The HRV parameters in diabetic group were significantly lower than those in control group (P <0.05), while the serum P-selectin levels were significantly higher than those in control group (P <0.05), and HRV was negatively correlated with serum P-selectin level (r = -0.27 r, = -0.17 r, = -0.26, P <0.05). Conclusion The changes of cardiac autonomic nervous function in diabetic patients are correlated with the changes of serum P-selectin level.