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近几年来,长效处方设计的研究已达高期。在此领域内,由合成聚合物作为配方中的主要成分,已有相当数量的研究成果报道,并有许多方法可资利用。过去大多采用非降解的聚合物,不过可生物降解聚合物的某些应用还是很有价值的。控制释放量在时间测算上,可设想以数周甚至常以数月计。这些生物降解系统的应用范围,包括避孕药植入剂或注射剂(要求甾族化合物恒定释放可达一年)以及可注射用的配方(如某些抗癌治疗所用的靶射技术,将药物浓集在一特定部位)。最近,有人对长效剂型的命名和控制药物释放制品的分类作了归纳讨论,认为有必
In recent years, the study of long-term prescription design has reached a high stage. In this field, a large number of studies have been reported on synthetic polymers as the main components in the formulation, and many methods are available. In the past most non-degradable polymers were used, but some applications of biodegradable polymers are still valuable. Controlled release in the time measured, it is envisaged in a few weeks or often months. Applications of these biodegradable systems include contraceptive implants or injections (requiring constant release of steroids up to one year) and injectable formulations (such as target-shooting techniques used in some anticancer therapies that concentrate the drug Set in a specific area). Recently, some people have summarized the classification of long-acting dosage forms and controlled drug release products, and considered it necessary