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目的 分析 336例葡萄胎患者化疗前后血清中 IL - 2和 SIL - 2 R含量的变化。方法 采用免疫化学法测定患者血清中 IL - 2和 SIL - 2 R含量 ,并与 35名健康人作对照。结果 化疗前 IL - 2活性明显低于正常人 ,SIL -2 R水平明显高于正常人 (P<0 .0 1) ,化疗后 6个月复发者 IL- 2 / SIL- 2 R水平持续异常。未复发者 IL- 2 / SIL- 2 R水平恢复正常。结论 观察患者免疫功能的变化对葡萄胎患者的病情和预后密切相关。
Objective To analyze the changes of serum IL-2 and SIL-2R levels in 336 patients with hydatidiform mole before and after chemotherapy. Methods The levels of IL-2 and SIL-2R in the serum of patients were measured by immunochemistry and compared with 35 healthy controls. Results The activity of IL-2 before chemotherapy was significantly lower than that of normal subjects. The level of SIL-2R was significantly higher than that of normal subjects (P<0.01). The level of IL-2/SIL-2R remained abnormal after 6 months of chemotherapy. . The level of IL-2 / SIL-2 R returned to normal without relapse. Conclusion Observing the changes of the immune function of patients is closely related to the condition and prognosis of patients with hydatidiform mole.