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目的:观察舒郁合剂对抑郁症肝郁脾虚型患者血清五羟色胺(5-HT)含量的影响。方法:将100例抑郁症患者,随机分为治疗组和对照组各50例,治疗组服用舒郁合剂,对照组服用盐酸氟西汀胶囊,对两组患者治疗前后进行汉密尔顿抑郁量表(HAMD)评定、血清5-HT含量变化进行比较。结果:治疗8周后两组患者血清5-HT含量较治疗前均升高,差异有统计学意义(P<0.05);治疗后治疗组5-HT含量略高于对照组,但差异无统计学意义(P>0.05)。结论:舒郁合剂能够提高抑郁症患者血清5-HT的含量。
Objective: To observe the effects of Shuyu Mixture on serum serotonin (5-HT) content in patients with depression and liver qi stagnation syndrome. Methods: One hundred patients with depression were randomly divided into treatment group (50 cases) and control group (50 cases). The treatment group took Shuyu Mixture while the control group took Fluoxetine Hydrochloride Capsule. The Hamilton Depression Inventory (HAMD) ) Assessment, serum 5-HT content changes were compared. Results: After 5 weeks of treatment, the serum 5-HT levels in both groups were significantly higher than those before treatment (P <0.05). After treatment, the content of 5-HT in the treatment group was slightly higher than that in the control group, but the difference was not statistically significant Significance (P> 0.05). Conclusion: Shuyu mixture can increase the content of serum 5-HT in patients with depression.