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目的探讨ｂｃｌ－２和ｂａｘ与肝癌发生的关系。方法用免疫组化方法研究３４例肝癌组织中ｂｃｌ－２和ｂａｘ的表达及与ＰＣＮＡ的关系。结果显示３４例肝细胞癌中５例ｂｃｌ－２阳性，阳性率为１４．７％，８例癌旁组织阳性，阳性率为２３．５％。７例ｂａｘ阳性，阳性率为２０．６％，癌旁组织２２例阳性，阳性率为６４．７％。ｂｃｌ－２和ｂａｘ表达与ＰＣ－ＮＡ增殖指数间无明显关系（Ｐ＞０．０５）。结论ｂｃｌ－２和ｂａｘ的变化可能影响肝细胞的凋亡状态，在肝癌发生中可能起一定作用，而并不引起细胞的增殖。
Objective To investigate the relationship between bcl-2 and bax and the occurrence of hepatocellular carcinoma. Methods The expression of bcl-2 and bax and the relationship with PCNA in 34 cases of hepatocellular carcinoma were studied by immunohistochemistry. The results showed that 5 out of 34 cases of hepatocellular carcinoma were positive for bcl-2, with a positive rate of 14.7%, and 8 cases were positive for paracancerous tissues, with a positive rate of 23.5%. 7 cases of bax were positive, the positive rate was 20.6%, paraneoplastic tissue was positive in 22 cases, and the positive rate was 64.7%. There was no significant relationship between bcl-2 and bax expression and PC-NA proliferation index (P>0.05). Conclusion The changes of bcl-2 and bax may affect the apoptotic state of hepatocytes and may play a role in the occurrence of hepatocarcinogenesis without causing cell proliferation.