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研究了吗啡和甲硫脑啡肽对束缚+寒冷刺激引起的大鼠应激性胃粘膜损害的影响。结果表明:外周静脉注射吗啡和甲硫脑啡肽均能降低应激性胃粘膜损害指数,但甲硫脑啡肽的作用较吗啡为弱。纳洛酮能部分地翻转吗啡和甲硫脑啡呔的抑制效应。提示,吗啡和甲硫脑啡肽能减轻应激性胃粘膜损害的程度,其作用与阿片受体有关。
The effects of morphine and met-enkephalin on stress-induced mucosal damage in rats induced by restraint + cold stimulation were studied. The results showed that both morphine and methotrexate decreased the gastric mucosal damage index, but the effect of methionine was weaker than that of morphine. Naloxone partially reversed the inhibitory effects of morphine and methotrexate. Tip, morphine and met-enkephalin can reduce stress gastric mucosal damage, its role and opioid receptor.