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Gastric cancer usually is diagnosed in advanced stages and thus current medical practice affords limited therapeutic options.However,recent studies established the role of human epidermal growth factor receptor 2(HER2)in clinical management.Trastuzumab,an antiHER2 monoclonal antibody,acquired a main role in advanced gastric cancer harboring HER2 overexpression and/or amplification improving survival to 17.1 mo according to trastuzumab for gastric cancer phaseⅢtrial results.Also,new promising drugs,such as c-Met inhibitors,are in development and assessment for this setting.Certainly,novel drugs will emerge in the next feel years for help oncologists improve clinical management of advanced gastric cancer providing higher survival and quality of life.In this mini-review we will discuss some issues in this regard and provide an actual overview of this setting.
Recent studies established the role of human epidermal growth factor receptor 2 (HER2) in clinical management. Trastuzumab, an antiHER2 monoclonal antibody, acquired a main role in advanced gastric cancer harboring HER2 overexpression and / or improvement improving to 17.1 mo according to trastuzumab for gastric cancer phase IIItrial results. Also, new promising drugs, such as c-Met inhibitors, are in development and assessment for this setting. drugs will emerge in the next feel years for help oncologists improve clinical management of advanced gastric cancer providing higher survival and quality of life. In this mini-review we will discuss some issues in this regard and provide an actual overview of this setting.