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α_1-酸性糖蛋白(α_1-AGP)是血清微量蛋白之一,其分子量为40,000,等电点pH2.7,电泳移动时在α_1位置,分子结构为单链,含糖总量为37.9％,属急性相反应物。近年来发现很多肿瘤病人血清α_1-AGP含量增高,被认为可能是一种与肿瘤有关的成份,可视为肿瘤的一种标志物。本文以火箭电泳法测定老年前期和老年期健康人,老年肿瘤(主要是胃肠道肿瘤)患者和冠心、慢支、糖尿病患者的α_1-AGP,探讨其临床意义。
Α_1-acid glycoprotein (α_1-AGP) is one of the microproteins in serum. Its molecular weight is 40,000, and the isoelectric point is pH 2.7. During electrophoresis, it moves at the position of α_1, the molecular structure is single-stranded, and the total sugar content is 37.9%. An acute phase reactant. In recent years, it has been found that many patients with tumors have elevated serum α 1 -AGP levels, which is considered to be a tumor-related component and can be regarded as a tumor marker. In this paper, rocket electrophoresis method was used to determine the preclinical and elderly healthy patients, elderly patients (mainly gastrointestinal cancer) and patients with coronary heart disease, chronic bronchitis, and diabetes.