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引言乌拉坦(Urethan,氨基甲酸乙酯)是中枢神经系统抑制药。1943年 Nettleship 等第一次发现乌拉坦可以诱发小鼠肺腺瘤,继而一些人把它当作两阶段致癌过程中的始发剂(Initiating agent)用来检验所复合的其它因子的促癌作用(Promoting action)。曾经与乌拉坦联合使用的有复合吸入二氧化钚对肺肿瘤发生的影响~2;复合 X 射线照射对自发肿瘤发生率的影响~3;以及复合皮肤涂抹巴豆油对诱发小鼠皮肤癌的影响。
Introduction Urethan (Urethane) is a central nervous system inhibitor. In 1943 Nettleship et al. first discovered that urethane could induce mouse lung adenomas, and then some people used it as an initiating agent in the two-stage carcinogenesis process to test the carcinogenic effects of the other complex factors. (Promoting action). Combined use of inhaled thorium dioxide with urethane has had an impact on lung tumorigenesis ~2; composite X ray irradiation has affected the incidence of spontaneous tumor ~3; and composite skin smeared with croton oil has induced skin cancer in mice. .