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包括上皮成份及骨与软骨等间质成份的恶性乳腺肿瘤是罕见的。至今,文献中仅报道200例。在纤维腺瘤、导管内乳头状瘤、叶状囊性肉瘤和乳腺间质肉瘤中,都可见成熟的和未成熟的骨与软骨病灶。但在明显的浸润癌中这几种成份的致病机理却一直不清楚。早期的报道认为,癌肿由于某些原因引起邻近基质的肉瘤性增殖。目前则认为,肿瘤上皮成份的化生乃产生假肉瘤状图象。
Malignant breast tumors, including epithelial components and interstitial components such as bone and cartilage, are rare. To date, only 200 cases have been reported in the literature. Mature and immature bone and cartilage lesions are found in fibroadenoma, intraductal papilloma, cystic sarcoma, and mammary stromal sarcoma. However, the pathogenesis of these components in apparent invasive cancer has remained unclear. Early reports suggested that cancer caused sarcomatous proliferation of adjacent matrices for some reason. At present, it is believed that the metaplasia of tumor epithelial components produces a false sarcomatoid image.