应用免疫组织化学方法，观察低分子细胞角蛋白（ＣＫ－ＬＭＷ）、神经烯醇化酶（ＮＳＥ）、嗜铬粒蛋白（ＣｇＡ）、突触泡蛋白（Ｓｙｎ）和α_１－抗胰蛋白酶（α_１－ＡＴ）在细支气管肺泡癌、肺乳头状腺癌、肺大细胞癌癌组织中的表达。结果发现，三型肺癌均有神经内分泌分化，细支气管肺泡癌和乳头状腺癌具有多种细胞分化成分。结果支持肺癌细胞来源于共同干细胞的假说。同时说明，在肺癌病理诊断上，免疫组织化学方法具有较为实用的价值。 Immunohistochemistry was used to observe low-molecular cytokeratin (CK-LMW), neuronenolase (NSE), chromogranin (CgA), synaptobrevin (Syn), and α_1-antitrypsin (α_1- AT) Expression in bronchioloalveolar carcinoma, lung papillary adenocarcinoma, and lung large cell carcinoma. The results showed that all three types of lung cancer have neuroendocrine differentiation, and bronchioloalveolar carcinoma and papillary adenocarcinoma have multiple cell differentiation components. The results support the hypothesis that lung cancer cells are derived from common stem cells. At the same time, the immunohistochemical method has practical value in the pathological diagnosis of lung cancer.