已知血浆微循环漏出是呼吸道疾病中的一种炎性反应。各种炎症介质如组胺、白三烯和速激肽都可引起气道微血管漏出反应,其确切机制有待进一步阐明。近来,有关NO的一些研究证实NO在血管渗透性中起作用,但对其具体调节作用仍有争议。作者已证实NO合成酶(NOS)抑制剂可抑制致敏豚鼠体内抗原诱导的血浆漏出,本研究目的在于用NOS抑制剂检测NO在炎症介质引起的气道微循环漏出中的作用,以及此作用是否与cGMP产物有关。 Leakage of plasma microcirculation is known to be an inflammatory response in respiratory disease. A variety of inflammatory mediators such as histamine, leukotrienes and tachykinins can cause airway microvascular leakage reaction, the exact mechanism needs further elucidation. Recently, some studies on NO have demonstrated that NO plays a role in vascular permeability, but its specific regulatory role remains controversial. The authors have demonstrated that NO synthase (NOS) inhibitors inhibit antigen-induced plasma leakage in sensitized guinea pigs and that this study aims to examine the role of NO in the presence of inflammatory mediators of airway microcirculation leakage with NOS inhibitors and this effect Is it related to cGMP products?