对３０例单侧湿性老年黄斑变性患者的对侧眼进行了５年以上的长期随诊。眼底检查及眼底荧光血管造影，半数患者显示正常，其余患者有黄斑玻璃膜疣和／或色素上皮改变；４例分别于５、６、１０、与１１年后发生视网膜下新生血管膜。初诊时黄斑玻璃膜疣与色素上皮改变各１例，眼底大致正常者２例。提示单侧湿性老年黄斑变性的另一只眼可能在很长时期以后发病。 Long-term follow-up of more than 5 years was performed in 30 patients with unilateral wet AMD. Fundus examination and fundus fluorescein angiography, half of the patients showed normal, and the remaining patients had macular drusen and / or pigmented epithelial changes; 4 cases were subretinal neovascular membrane in 5,6,10, and 11 years respectively. Newly diagnosed macular drusen and pigmented epithelial changes in 1 case, the fundus of the eye was normal in 2 cases. Prompted unilateral wet age-related macular degeneration in the other eye may be a long period of time after the onset.