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本文通过前瞻双盲对照的方法,观察西米替丁对输血过敏反应的影响。临床资料上消化道出血患者,依其输血前是否用西米替丁而分为西米替丁组(输血前西米替丁0.3～0.6g 静脉滴注)和对照组。统计时删除输血前使用H_1受体阻滞剂、糖皮质激素及肾上腺素之病例,两组病人(西米替丁组:对照组)在性别(男/女=2.0:1.9)、年龄(52.6±16.9:53.6±15.3岁)、输血前血红蛋白(69.6±22.6:67.3±21.6g/L),血型(A/B/O/AB=27.6%/26.3%/38.2%/7.9%/:31.3%/31.3%/32.8%6/4.7%)、输入血储存时间(3.4±2.7:4.6±3.1天)、输血量(0.5±0.2:0.4±0.2L)以及上消化道出血原因等方面均无显著差异。
In this paper, prospective double-blind control method to observe the impact of cimetidine on transfusion allergic reactions. Patients with upper gastrointestinal bleeding were divided into cimetidine group (0.3-0.6 g intravenous infusion of cimetidine before transfusion) and control group according to whether cimetidine was used before transfusion. Patients in the two groups (cimetidine: control group) had significant differences in gender (male / female = 2.0: 1.9), age (52.6 ± 16.9: 53.6 ± 15.3 years), pre-transfusion hemoglobin (69.6 ± 22.6: 67.3 ± 21.6 g / L) and blood type (A / B / O / AB = 27.6% / 26.3% / 38.2% / 7.9% /: 31.3% /31.3%/32.8%6/4.7%). There was no significant difference in the time of blood storage (3.4 ± 2.7: 4.6 ± 3.1 days), blood transfusion (0.5 ± 0.2: 0.4 ± 0.2L) and upper gastrointestinal bleeding difference.