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目的探讨原发性中枢神经系统淋巴瘤(PCNSL)的外科诊断及治疗方法。方法回顾性分析南京鼓楼医院神经外科手术治疗并术后病理确诊为PCNSL的50例患者的临床资料,分析其临床表现、影像学特点、病理学特征、并结合文献探讨其诊断及治疗。结果 50例行手术治疗,其中8例颅内多发占位者仅行立体定位活检,24例单发占位行全切,18例单发占位行次全切,围手术期无一例死亡。明确病理学诊断后,于肿瘤科行进一步治疗。结论 PCNSL是一种罕见的中枢神经系统恶性肿瘤,易误诊。PCNSL整体预后差,包括手术、放疗、化疗在内的综合治疗目前仍是临床一线的治疗措施。
Objective To investigate the surgical diagnosis and treatment of primary central nervous system lymphoma (PCNSL). Methods We retrospectively analyzed the clinical data of 50 patients with neurosurgical neurosurgery in Nanjing Drum Tower Hospital who were pathologically diagnosed as PCNSL and analyzed their clinical manifestations, imaging features and pathological features, and discussed their diagnosis and treatment based on the literature. Results Fifty patients underwent surgical treatment. Among them, 8 patients with multiple intracranial multiple occupancy were treated with stereotactic biopsy only. Twenty-four patients underwent solitary mass biopsy and 18 patients underwent solitary mass biopsy. There was no death during the perioperative period. Clear pathology diagnosis, in the oncology further treatment. Conclusion PCNSL is a rare malignancy of the central nervous system and is easily misdiagnosed. Overall poor prognosis of PCNSL, including surgery, radiotherapy, chemotherapy, including comprehensive treatment is still a clinical frontline treatment.