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目的探讨抽动－秽语综合征（ＴＳ）和慢性运动性抽动障碍（ＣＭＴＤ）的关系及两者脑电图、局部脑血流（ｒＣＢＦ）的异常。方法对３８例ＴＳ和２５例ＣＭＴ进行临床症状和２４小时脑电监测（ＡＥＥＧ）及部分患儿用单光子发射计算机断层扫描（ＳＰＥＣＴ）观察ｒＣＢＦ的变化。结果ＴＳ的临床症状较ＣＭＴＤ严重，两者ＡＥＥＧ异常率分别为５０％和５２％，均以额区明显，５例有痫样放电。ＴＳ和ＣＭＴＤ的ｒＣＢＦ异常呈降低或增加改变，波及范围广泛，与ＡＥＥＧ异常部位无一致性。结论ＣＭＴＤ是ＴＳ的临床表型，两者的脑电图和ｒＣＢＦ异常与癫痫相似，提示与癫痫有一定关系。
Objective To investigate the relationship between TS and CMTD and the abnormalities of EEG and regional cerebral blood flow (rCBF). Methods The changes of rCBF in 38 patients with TS and 25 patients with CMT undergoing echocardiography (ECG) and 24-hour electroencephalogram (AEEG) and some patients by single photon emission computed tomography (SPECT) were observed. Results The clinical symptoms of TS were more serious than those of CMTD. The abnormal rates of AEEG in both groups were 50% and 52% respectively, both of which were significant in frontal area and 5 cases of epileptiform discharge. The abnormalities of rCBF in TS and CMTD showed a decrease or increase change with a wide range of spread and no consistency with the abnormal site of AEEG. Conclusions CMTD is the clinical phenotype of TS. Both EEG and rCBF abnormalities are similar to epilepsy, suggesting that there is a certain relationship between epilepsy and CMTD.