掌跖角化—牙周病综合征(Papillon-Lefèvre syndrome,简称P—LS)1924年首先由Papillon和Lefèvre所报告,是一种临床上罕见的疾病。患病率约为1～4/百万。其特征是掌跖角化过度合并有过早的牙周组织破坏和乳恒牙脱落。我国对本病报道较少,我科自1978年以来共接诊3例,现报告如下,并综合国内病例加以讨论。 Palmoplantar keratosis - Papillon-Lefèvre syndrome (P-LS), first reported by Papillon and Lefèvre in 1924, is a clinically rare disease. The prevalence is about 1 ~ 4 / million. It is characterized by an excessive combination of palmoplantar keratosis with periodontal tissue destruction and the loss of primary and permanent teeth. There are few reports on this disease in our country. Three cases have been treated in our department since 1978, and the report is as follows, and the domestic cases are discussed.