目的观察2.5%5氟脲嘧啶(5-Fu)溶液持续湿敷法治疗男性尿道尖锐湿疣的安全性和有效性。方法 16例男性患者,12例曾行激光、电灼、微波等局部治疗。以2.5%5-Fu 溶液浸透的棉片覆盖相应的疣体,其它部位用胶带隔离并固定。1小时后以自配液湿敷30分钟以减轻炎症水肿。每日2次,10天为一疗程。结果16例患者经治疗后全部达到痊愈,其中一个疗程治愈者1例,两个疗程治愈者3例,三个疗程治愈者9例,四个疗程治愈者2例,五个疗程治愈者1例。结论 2.5%5-Fu 溶液治疗男性尿道尖锐湿疣安全有效,而且患者痛苦小,顺从性好。 Objective To observe the safety and efficacy of 2.5% 5-fluorouracil (5-Fu) continuous wet compress in the treatment of male urethral condyloma acuminatum. Methods 16 cases of male patients, 12 cases of laser, electrocautery, microwave and other local treatment. The warts were covered with cotton sheets soaked in 2.5% 5-Fu solution and the other parts were separated and fixed with tape. After 1 hour with self-wetting 30 minutes to reduce the inflammatory edema. 2 times a day, 10 days for a course of treatment. Results All of the 16 patients recovered after treatment. Among them, one was cured by one course, three were cured by two courses, three were cured by three courses, two were cured by four courses and one was cured by five courses . Conclusions 2.5% 5-Fu solution is safe and effective for treating male urethral condyloma acuminatum, and the patient has less pain and good compliance.