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本工作观察了降钙素基因相关肽（ＣＧＲＰ）对小鼠肠集合淋巴小结（ＰＰ结）Ｔ细胞和小鼠腹腔巨噬细胞功能的影响。结果表明：ＣＧＲＰ能明显抑制ＰＰ结Ｔ淋巴细胞的转化，并且这种作用与Ｔ细胞的分化增殖状态有明显关系。此外ＣＧＲＰ对腹腔巨噬细胞ＤＮＡ和蛋白质的合成也有明显的抑制作用。以上结果提示ＣＣＲＰ可能作为一种抑制型的神经内分泌免疫调节肽而对肠道免疫功能发挥着重要的调节作用。
This study investigated the effects of calcitonin gene related peptide (CGRP) on the function of murine intestinal aggregated lymph node (PP) T cells and mouse peritoneal macrophages. The results showed that: CGRP can significantly inhibit the transformation of PP T lymphocytes, and this effect has a clear relationship with the differentiation and proliferation status of T cells. In addition CGRP peritoneal macrophages DNA and protein synthesis also significantly inhibited. The above results suggest that CCRP may play an important regulatory role in intestinal immune function as an inhibitory neuroendocrine immunomodulatory peptide.