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研究马蹄香Saruma henryi Oliv.全草的化学成分.利用溶剂萃取,反复硅胶、硅藻土色谱等手段进行分离纯化,根据理化性质、谱学数据进行结构鉴定.分离并鉴定了13个化合物,分别为7-甲氧基-马兜铃内酰胺Ⅳ(1)、马兜铃内酰胺Ⅱ(2)、马兜铃酸Ⅰ(3)、马兜铃内酰胺AⅡ(4)、胡萝卜苷(5)、马兜铃内酰胺Ⅰa(6)、穆坪马兜铃酰胺(7)、马兜铃内酰胺Ⅰ(8)、4p,10β-香兰木二醇(9)、马兜铃内酯(10)、马兜铃次酸Ⅰ(11)、内消旋二氢愈疮木酸(12)、calopiptin(13).所有化合物均为首次从马蹄香属植物中分离得到.马兜铃酸和马兜铃内酰胺类成分具肾毒性,本研究提示马蹄香药用的安全问题值得关注;研究结果亦为马兜铃科的化学分类学提供了依据.“,”Chemical constituents of the whole herb of Saruma henryi Oliv. were investigated. The herbal extract was separated by repeated column chromatography over silica gel and celite. The structures were elucidated by spectroscopic analysis. Thirteen compounds were obtained and identified as 7-methoxyi-aristololactam IV (1), aristololactam H (2), aristolochic acid I (3), aristololactam AⅡ (4), daucosterol (5), aristololactam Ia (6), N-trans-feruloyl tyramine (7), aristololactam Ⅰ (8), 4β,10β-aromadendranediol (9),aristololide (10), adstolic acid Ⅰ (11), meso-dihydroguaiaretic acid (12), and calopiptin (13). These compounds were obtained from the genus Saruma for the first time, and they provided chemical evidences for the chemotaxonomy of plants of the Aristolochiaceae family.Since aristoiochic acids and aristololactams are toxic to kidney, the results of this investigation suggest that it should be cautious to use Saruma henryi as a medicine.