肿瘤抑制基因ｐ５３，Ｒｂ，ｐ１６，ｎｍ２３等参与调控肿瘤细胞等多种细胞的凋亡。它们既具有单一的调节作用，又具有复杂的协同效应。研究这些基因在细胞凋亡中的调控机制，对利用基因治疗技术治疗恶性肿瘤具有重要意义 Tumor suppressor genes such as p53, Rb, p16, and nm23 are involved in the regulation of apoptosis in a variety of cells such as tumor cells. They have both a single regulatory role and a complex synergistic effect. Studying the regulatory mechanisms of these genes in cell apoptosis has important implications for the use of gene therapy technology for the treatment of malignant tumors.