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目的探讨山奈酚对实验性乳腺癌抑郁大鼠的抗抑郁作用。方法 90只大鼠随机分为对照组、乳腺癌组、抑郁组、复合模型组、氟西汀组、山奈酚组,每组15只。通过慢性不可预知性轻度应激方法建立大鼠抑郁模型,以二甲基苯蒽为诱导剂建立乳腺癌大鼠模型。采用旷场实验垂直运动次数及水平活动总路程观察各组大鼠自主活动;液质联检分析各组大鼠脑内海马及前额叶皮质单胺类神经递质,包括去甲肾上腺素(norepinephrine,NE)、多巴胺(dopamine,DA)和5-羟色胺(5-hydroxytryptamine,5-HT)含量的变化。结果乳腺癌组自主活动均减少,但与对照组比较无显著性差异;抑郁组和复合模型组自主活动减少,与对照组比较差异均有显著性(P<0.01);与复合模型组相比,山奈酚组与氟西汀组垂直运动次数及水平活动总路程均显著增加(P<0.05或P<0.01)。与复合模型组比较,氟西汀组海马区DA、5-HT含量显著增高(P<0.01),前额叶皮质DA、NE、5-HT浓度均显著性增高(P<0.05);山奈酚组与复合模型组比较,海马部位NE含量明显增高(P<0.05),前额叶皮质部位DA、NE、5-HT浓度均显著性增高(P<0.05或P<0.01)。结论山奈酚具有显著抗大鼠抑郁作用,可能通过提高前额叶皮质部位NE、DA、5-HT递质水平达到抗抑郁作用。
Objective To investigate the antidepressant effect of kaempferol on experimental breast cancer depression in rats. Methods Ninety rats were randomly divided into control group, breast cancer group, depression group, compound model group, fluoxetine group and kaempferol group. The rat model of depression was established by chronic unpredictable mild stress. The rat model of breast cancer was established by using dimethylbenzyl anthracene as an inducer. The number of vertical movement and the total distance of horizontal movement were used to observe the autonomic activity of rats in each group. The levels of monoamine neurotransmitters, including norepinephrine (norepinephrine) (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT). Results Compared with the control group, the autonomic activities decreased in the breast cancer group, but there was no significant difference between the two groups (P <0.01). The autonomic activity decreased in the depression group and the compound model group compared with the control group (P <0.01) (P <0.05 or P <0.01). The frequency of vertical movement and the total distance of horizontal activity in kaempferol group and fluoxetine group were significantly increased (P <0.05 or P <0.01). Compared with compound model group, the content of DA and 5-HT in hippocampus of fluoxetine group was significantly increased (P <0.01), the concentration of DA, NE and 5-HT in prefrontal cortex were significantly increased (P <0.05) Compared with the compound model group, the content of NE in hippocampus was significantly increased (P <0.05), and the concentration of DA, NE and 5-HT in prefrontal cortex were significantly increased (P <0.05 or P <0.01). Conclusions Kaempferol has a significant antidepressant effect on rats and may have an antidepressant effect by increasing NE, DA and 5-HT levels in the prefrontal cortex.