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分离纯化得杜仲5种降压成分。以SD大鼠的胸动脉条为标本,对比杜仲的各种降压成分单独在不同浓度水平下及它们之间正交组合之后舒张血管的效果与杜仲的水提物有何差异。实验结果表明,杜仲中各种降压成分及其组合都有不同程度的舒张率,很多组分组合后还超过了杜仲的水提浸膏在中剂量下的舒张率。其中各组分单独进样时以京尼平苷和京尼平苷酸这两种组分舒张率的值最大,组合进样时以绿原酸(0.25mg/ml)加京尼平苷(1.0mg/ml)加京尼平苷酸(0.5mg/ml)加木脂素(0.25mg/ml)这种组合舒张率最大,有显著舒张血管的效果。
Eucommia isolated and purified 5 kinds of antihypertensive ingredients. Thoracic artery strips of SD rats were used as samples to compare the effect of various antihypertensive components of Eucommia ulmoides on the effect of relaxing blood vessels and the aqueous extract of Eucommia ulmoides under different concentration levels and orthogonal combination between them. The experimental results show that various antihypertensive ingredients and combinations of Eucommia ulmoides have different degrees of relaxation rate, and many of the components also exceed the relaxation rate of Eucommia ulmoides extract at medium dosage. The components of which were injected with geniposide and geniposidic both components of the diastolic value of the maximum, combined with chlorogenic acid (0.25mg / ml) plus geniposide ( 1.0 mg / ml) plus geniposidic acid (0.5 mg / ml) plus lignans (0.25 mg / ml) This combination has the highest relaxation rate with a significant vasodilatation effect.