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自Ferreira 从巴西蛇毒中分离出具有降压活性的多肽物质,并由Ondetti 等进行人工合成以来,对这类物质的研究迅速展开,很快就形成一类引人注目的新型降压药——血管紧张素转化酶抑制剂(下称转化酶抑制剂)。近年来,使用本类药物治疗高血压病的临床报道日益增多,新的转化酶抑制剂亦不断出现。其中甲巯丙脯酸(SQ_(14225),Captopril)经多种动物实验及临床试用表明,具有作用强、毒性小、可口服等优点,国内亦试制成功并开始用于临床。
Since Ferreira isolated from Brazil snake venom peptide compounds with antihypertensive activity, synthesized by Ondetti et al. Since the rapid development of such substances, and soon the formation of a new type of attractive antihypertensive drugs - Angiotensin converting enzyme inhibitors (hereinafter referred to as invertase inhibitors). In recent years, the use of this class of drugs for the treatment of hypertension increasingly clinical reports, new invertase inhibitors also continue to appear. Among them captopril (SQ_ (14225), Captopril) by a variety of animal experiments and clinical trials show that with strong effects, toxicity, can be oral and other advantages, the domestic trial is also successful and began to be used clinically.