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Purpose To report a case of primary in traocular lym-phoma possessing bilaterally ident ical monoclonal rear-rangements of the immunoglobulin heavy chain(IgH)gene.Design Observational case rep ort.Methods A 78-year-old woman with bilateral vitritis,subretinal infil-trates in the right eye,and no involv ement of the central nervous system(CNS)was diagnosed histologically with diffuse large B-cell lymphoma by a tr ansvitreal subretinal biopsy of the right eye.One month later,vitrectomy was performed on the left eye due to incre ased vitreous opacity.DNA was extracted from a vitrectomy s pecimen from each eye,and the third complementarity-determining region of IgH gene was analyzed by polymerase c hain reaction and direct sequencing.Results Monoclo nal rearrangements of IgH gene with identical DNA sequence were detected in both eyes.Conclusions Bilaterally identical monoclonality was detected in a case of primary intr aocular lymphoma with no CNS involvement.
Purpose To report a case of primary in tracular lym-phoma possessing bilaterally ident ical monoclonal rear-rangements of the immunoglobulin heavy chain (IgH) gene. Design Observational case rep ت. Methods A 78-year-old woman with bilateral vitritis, subretinal infil -trates in the right eye, and no involvment of the central nervous system (CNS) was diagnosed histologically with diffuse large B-cell lymphoma by a tr ansvitreal subretinal biopsy of the right eye .One month later, vitrectomy was performed on the left eye due to incresed vitreous opacity. DNA was extracted from a vitrectomy s pecimen from each eye, and the third complementarity-determining region of IgH gene was analyzed by polymerase c hain reaction and direct sequencing. Results Monoclo nal rearrangements of IgH gene with identical DNA sequence were detected in both eyes. Conclusions Bilaterally identical monoclonality was detected in a case of primary intr aocular lymphoma with no CNS involvement.