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目前,有关同源性磷酸酶张力蛋白(PTEN)在上尿路上皮癌中的表达频率及预后价值并未在大量研究中得以阐述。本研究分析了PTEN在一个大型、多机构的队列研究中的重要性及其与疾病复发和生存结局的联系。回顾性分析了1991年至2008年间于7个不同机构接受根治性肾输尿管切除术的611例上尿路上皮癌患者的状况。中位随访期为23个月。研究进行了组织微阵列及免疫组织化学PTEN染色(单克隆抗体)。单变量和多变量比例回归模型说明PTEN蛋白的表达与疾病复发、肿瘤特异性死亡率及总死亡
At present, the frequency and prognostic value of homologous phosphatase (PTEN) in epithelial carcinoma of the upper urinary tract have not been elucidated in a large number of studies. This study analyzed the importance of PTEN in a large, multi-institutional cohort study and its association with disease recurrence and survival outcomes. A retrospective analysis of 611 patients with upper urothelial carcinoma who underwent radical nephroureterectomy at seven different institutions between 1991 and 2008 was performed. The median follow-up period was 23 months. Tissue microarrays and immunohistochemical PTEN staining (monoclonal antibodies) were studied. Univariate and multivariate proportional regression models demonstrated that PTEN protein expression correlated with disease recurrence, tumor-specific mortality, and overall mortality