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关于氯霉素的一般毒性已有不少报道,但对其遗传毒性所知不多,尚缺乏系统的实验资料。作者对氯霉素的胚胎及遗传毒性进行了较系统的研究。本实验以Wistar大鼠子一代精子形态、数量、活动度等为指标,观察母鼠在孕期接触氯霉素后对胎鼠的影响,旨在为这方面的研究提供一些动物实验资料。 1 材料与方法 1.1 被测物质 市购杭州民生药厂生产的氯霉素注射液(Chloramphenicol injectio,CAP),浙卫药佳字(82)
There are many reports on the general toxicity of chloramphenicol, but little is known about its genotoxicity, and systematic experimental data are still lacking. The author of chloramphenicol embryos and genetic toxicity conducted a more systematic study. In this study, the Wistar rat sperm morphology, number, activity, etc. as an indicator to observe the impact of maternal exposure to chloramphenicol during pregnancy fetal rats, designed to provide some animal experimental data in this regard. 1 Materials and methods 1.1 The test substance purchased Hangzhou Minsheng Pharmaceutical Factory production of chloramphenicol injection (Chloramphenicol injectio,