口服难溶于水的药物后,其吸收速率受其在胃肠道中溶解速率所控制。作者通过制备难溶性药物与PVP共沉物来改进溶解性能,获得较好的生物利用度,并通过对碘胺异噁唑(SIZ)及磺胺甲基噻二唑(SMZ)与PVP共沉物的溶解特性及机制的研究,提出药物-PVP共沉物新的溶解模式。实验结果表明,SMZ-PVP共沉物的溶解速率比单独的SMZ或SMZ与PVP的物理混合物的溶解要 After oral administration of a poorly water-soluble drug, its rate of absorption is governed by its rate of dissolution in the gastrointestinal tract. By improving the solubility and improving the bioavailability of PVP by preparing insoluble drug and PVP co-precipitate, the authors obtained the best bioavailability by the combination of SIZ and sulfapyrothiadiazole (SMZ) with PVP Of the dissolution characteristics and mechanism of the proposed drug-PVP coprecipitate new dissolution mode. The experimental results show that the dissolution rate of the SMZ-PVP coprecipitate is higher than that of the SMZ alone or the physical mixture of SMZ and PVP